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2010/1 Module Catalogue
Module Provider: Biosciences Short Name: GTXM005
Level: M Module Co-ordinator: PRICE SC Prof (Biosciences)
Number of credits: 15 Number of ECTS credits: 7.5
Module Availability
15-19 November ‘10
14-18 November ‘11
Assessment Pattern
Unseen 2.5 h written examination on the Friday of the module (50%)
Home-based assignment to be submitted within ten weeks (50%)
Module Overview
Module Aims
Learning Outcomes

Learning Outcomes:


The aims of this module are that the students will be able to understand:


·         Principles of Phase 1 and Phase 2 metabolism.


·         Tissue specificity.


·         Relationships to activation of chemicals.


·         Activation preparation


·         Human variation.


·         Polymorphism/SNPs etc,


·         Individual genotyping and relationship to pharmaceutical development.


·         Engineered cell lines.



On the successful completion of the module the students should be able to assess study reports in the context of overall toxicological evaluation. They will:


·         understand the major pathways of xenobiotic metabolism in mammals


·         appreciate the significance of metabolism in genetic toxicology


·         appreciate the major species differences in metabolism and their significance for toxicity testing


·         understand the principles of toxicokinetics and be able to compare and contrast data sets.


·         be able to integrate knowledge of kinetics, dynamics and metabolism in the study of toxicity


Module Content

Module content:


·         General principles covering the passage of xenobiotic chemicals through the mammalian body


·         Pharmacokinetics, pharmacodynamics and toxicokinetics.


·         Metabolism, principles of Phase I metabolism, oxidation, reduction, hydrolysis. Enzymes involved.
Examples of toxicology.


·         The Cytochrome P450s, history of identification and characterisation.


·         Basic biochemistry. Classification, cloning and sequencing.


·         Genetic factors, polymorphisms and SNP’s. Examples of variation. Environmental factors, enzyme induction, inhibition. Phase 1


·         Genetic factors, polymorphisms and SNP’s Examples of variation. Environmental factors, enzyme induction, inhibition. Phase 2


·         Experimental activation preparations for Phase ½ metabolism.


·         Influence of metabolism on effects of genotoxic exposure. Case studies


·         Genetic engineering of cell lines. Development and application.


·         Enzyme variation, genotyping, pharmaceutical development


·         Food industry. Overview and future development.


Methods of Teaching/Learning
Selected Texts/Journals

Pre-course Reading :


·         Friedberg E.C., Walker , G.C., Siede, W., et al (2006) DNA Repair and Mutagenesis, 2nd edn, pub: ASM Press (ISBN 1-55581-319-4) [core reading for all modules of the MTP]


·         Gibson, G. and Skett, P. (2001) Introduction to Drug Metabolism


·         Clark, B. and Smith, D., (2001) An Introduction to Pharmacokinetics


·         A number of relevant papers will be selected from the Mutation Research journal.


Last Updated
February 2010