· General principles covering the passage of xenobiotic chemicals through the mammalian body
· Pharmacokinetics, pharmacodynamics and toxicokinetics.
· Metabolism, principles of Phase I metabolism, oxidation, reduction, hydrolysis. Enzymes involved.
Examples of toxicology.
· The Cytochrome P450s, history of identification and characterisation.
· Basic biochemistry. Classification, cloning and sequencing.
· Genetic factors, polymorphisms and SNP’s. Examples of variation. Environmental factors, enzyme induction, inhibition. Phase 1
· Genetic factors, polymorphisms and SNP’s Examples of variation. Environmental factors, enzyme induction, inhibition. Phase 2
· Experimental activation preparations for Phase ½ metabolism.
· Influence of metabolism on effects of genotoxic exposure. Case studies
· Genetic engineering of cell lines. Development and application.
· Enzyme variation, genotyping, pharmaceutical development
· Food industry. Overview and future development.