· The basic structure of human genome, the karyotype, gene organisation, nuclear and mitochondrial organisation.
· DNA structure, replication fidelity, base selection, enzymes and components of replication, mismatch repair correction of replication errors.
· Cell cycles, mitosis and meiosis, male and female germ cell cycles. Targets for chemical interactions, cell division, spindle etc. What happens when the gene signals go wrong?
· Types of gene mutations, base substitutions, insertions, deletions.
· Micro/mini satellite changes. Their influence on human health.
· Transposons and their significance, mechanisms of transposition.
· Chromosome changes, types of rearrangements and modifications of the karyotype.
· Gene mutation changes in human germ and somatic cells (including multifactorial disease), examples of gain and loss of function mutations
· Imprinting discussion of the most relevant examples of diseases, nuclear and mitochondrial changes.
· Chromosome changes, structural and numerical in human congenital disease, discussion of most relevant examples.
· Genetic changes in human cancer, oncogene and tumour suppressor gene changes.
· Chromosome structural and numerical changes in human cancers, e.g. such as translocation and aneuploidy in leukaemia’s.