BMS3072


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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE

Module Code: BMS3072

Module Title: SYSTEMS BIOLOGY: GENOMES IN ACTION

Module Provider: Biosciences	Short Name: BMS3072
Level: HE3	Module Co-ordinator: KIERZEK AM Dr (Biosciences)
Number of credits: 15	Number of ECTS credits: 7.5

Module Availability

Semester Two

Assessment Pattern

DEADLINE Week 5 Week 11

ASSESSMENT
Oral presentation
Practical report

WEIGHTING
30%
70%

Module Overview

Prerequisites/Co-requisites

Module Aims

To introduce the field of Systems Biology and the key topics within it.
To understand the high-throughput technologies ("-omics": genomics, phenomics, proteomics, transcriptomics and metabolomics) employed to measure parameters at a systems level.
To achieve practical understanding of computer simulations of living systems, computational analysis of experimental data and how to interpret the results.
To appreciate that integration of diverse data sets is needed to understand organisms at a systems level.

Learning Outcomes

On successful completion of this module you should be able to:

Understand the basic quantitative techniques used within the field of Systems Biology
Analyse high-throughput data sets using current available softwares/web-tools
Use key bioinformatic tools for interpreting your results.
Use software tools for computer simulations of molecular interaction networks.
Integrate diverse data sets to understand organisms at a systems level
Present your findings in a concise and cohesive report in the style of a sicientific paper
Present your findings in an oral presentation

Module Content

Lecture No:	Lecturer	Topic
1	AMK	What is Systems biology?
2	EL	Genomics : Sequence analysis
3	EL	Sequence analysis : Identification and annotation of genes and upstream region features. Computer based practical session.
4	EL	Phenomics & Proteomics
5	EL	Phenomic (Biolog) & Proteomic data analysis : Identifying substrate utilisation and the enzymes available. Computer based practical session.
6	EL	Transcriptomics: Microarrays
7	EL	Microarray data analysis : which genes are expressed? Computer based practical session.
8	AMK	Modelling genome scale metabolic networks
9	AMK	Modelling genome scale metabolic networks. Computer based practical session
10	AMK	Computer simulations of the cellular processes.
11	AMK	Computer simulations of the cellular processes. Computer based practical session
12	CAR	Metabolomics: Quantitative physiology
13	CAR	Metabolomics: Quantitative physiology. Computer based practical session.
14	CAR	Bioenergetics
15	CAR	Bioenergetics. Computer based practical session.
16	CAR	Metabolic control analysis : Determination of control coefficients. Control in linear and branched pathways
17	CAR	Metabolic control analysis : Computer based practical session.
18	AMK	Randomness of single cell behaviour
19	AMK	Randomness of single cell behaviour : Computer based practical session.

Methods of Teaching/Learning

Lectures, computer based practical sessions

Selected Texts/Journals

Recommended books:

Web sites and other resources:

E Klipp, W Liebermeister, C Wierling, A Kowald, H Lehrach, R Herwig. Systems Biology: A Textbook. Wiley VCH, 1st Edition, 2009, ISBN: 978-3527318742

Fell. Understanding the Control of Metabolism, Portland Press, ISBN 1-85578-047-X

Gibson and Muse. A Primer of Genome Science, Palgrave-MacMillan, ISBN 0-87893 2348

Louka. A Guide to Molecular Sequence Analysis, Downloadable from: www.SequenceAnalysis.Com

Kanehisa. Post-Genome Informatics, Oxford University Press, ISBN 0-19-850326-1

Schena (ed.) DNA Microarrays, Oxford University Press, ISBN 0-19-9637768

Higgins and Taylor (eds.) Bioinformatics, Oxford University Press, ISBN 0-19-963790-3

Links to organisations' websites and documents will be reviewed in week 2, a list of reading and useful resources will be identified.

Last Updated

19 April 2011