| Module Code: BMS3066 |
Module Title: BIOLOGICAL RHYTHMS |
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Module Provider: Biosciences
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Short Name: BMS3066
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Level: HE3
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Module Co-ordinator: SKENE DJ Prof (Biosciences)
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Number of credits: 15
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Number of ECTS credits: 7.5
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| Module Availability |
| Semester Two |
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| Assessment Pattern |
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Coursework (two short essays, deadline: week 9) 20%,
Examination 80%
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| Module Overview |
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| Prerequisites/Co-requisites |
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| Module Aims |
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| Learning Outcomes |
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On successful completion of this module you should be able to:-
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Describe the basic generation and control of circadian and seasonal rhythms
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Appreciate the interaction between central and peripheral clocks; photic and nonphotic time cues
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Understand theoretical concepts and assessment and control of rhythmicity
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Describe the effects of altered environments on human health (eg jet lag, shift work)
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Appreciate the contribution of underlying rhythm disturbances to pathology e.g. sleep problems, disorders of metabolism
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Describe new approaches to pharmacology through the development of chronobiotic drugs
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| Module Content |
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Lecture No:
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Lecturer
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Topic
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1
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DJS
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Basic principles: phase response curves, entrainment
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2
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DJS
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Basic principles: photic and nonphotic zeitgebers
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3
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tbc
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Clocks in plants, insects and birds
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4
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SNA
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Photoreception, ocular and extra-ocular
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5
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SNA
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Nonvisual light responses
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6
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SNA
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Photoreceptor systems: melanopsin, rods, cones
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7
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ESM
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SCN clock, molecular clockwork
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8
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ESM
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SCN clock, input and output pathways
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9
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JDJ
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Peripheral clocks,
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10
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SNA/JDJ
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Tutorial 1: Clock mechanisms
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11
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JDJ
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Clocks and metabolism
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12
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DJD
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Sleep and metabolism
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13
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MvS
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Clock genes: human polymorphisms, sleep disorders
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14
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MvS
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Clock genes: circadian and non circadian roles
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15
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DJS
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The pineal gland and melatonin, synthesis and metabolism
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16
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DJS
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Melatonin and the circadian system
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17
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DJS
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Melatonin: receptors, structure and function
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18
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JDJ
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Photoperiodism: neuroendocrine and molecular control
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19
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JDJ
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Circannual rhythms
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20
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MvS/JDJ
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Tutorial 2: Clocks and (metabolic?) diseases
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21
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D-JD
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Assessment of human circadian rhythms: protocols
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22
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D-JD
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Homeostatic and circadian regulation of sleep
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23
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DJS
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Circadian rhythm disorders: jetlag
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24
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DJS
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Shift work, health consequences, therapeutic strategies
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25
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DJS
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Blindness, a model for circadian studies
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26
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DJS
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Non 24 h sleep/wake disorder, treatment
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27
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MvS /DJD
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Clocks and psychiatry
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28
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DJD
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Ageing, sleep and the circadian timing system
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29
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DJS
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Ageing and nonvisual light responses
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30
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DJS, DJD
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Tutorial 3: Circadian rhythm disorders
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| Methods of Teaching/Learning |
| Lectures, tutorials |
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| Selected Texts/Journals |
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Recommended Books (in library):
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Human Circadian Rhythms: Regulation and Impact. Journal of Biological Rhythms, Aug 2005, Vol 20 (4) Special Issue.
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Melatonin and the Mammalian Pineal Gland. Arendt J, Chapman Hall, 1995.
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Chronobiology: Biological Timekeeping, Eds: Dunlap, J C and Loros, J J and DeCoursey P J,
Sinauer,
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Rhythms of Life - The Biological Clocks that Control the Daily Lives of Every Living Thing. Foster, R.G. and Kreitzman, L. Profile Books 2004 (hardback): 2005 (paperback).
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| Last Updated |
| 18 April 2011 |
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