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| Module Availability |
| Semester Two |
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| Assessment Pattern |
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Coursework 20% - 1 Essay (1,500 words, deadline week 10)
Examination 80%
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| Module Overview |
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| Prerequisites/Co-requisites |
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| Module Aims |
To give a broad overview of the development of malignant disease with emphasis on the molecular biology of the cancer cell.
To provide an understanding of how both exogenous and endogenous factors such as diet, viruses and xenobiotics contribute to the development of human cancers
To familiarise the student with aspects of malignant disease relating to haematological cancers and the most common solid tumours
To provide up to date information on new targeted therapies being developed for the use of cancers as well as familiarising the student with the principles of cancer chemotherapy drugs
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| Learning Outcomes |
On the successful completion of the module the student should be able to:-
Understand the factors responsible for the development of the most common forms of cancer
Appreciation of the development of cancers from early precancerous lesions to terminal disease from the viewpoint of histopathology
Understand how on can interfere with the development of cancers both in a chemo-preventative setting and also by the use of chemotherapeutic agents
Gain an understanding into the development and use of new targeted therapies based on rational design
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| Module Content |
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Lecture No:
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Lecturer
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Topic
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1 – 2
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HMC
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Introduction to cancer, causes, epidemiology etc.
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3 – 4
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BH
SCP/LM
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Histopathology and classification of cancer lesions, progression and metastases
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5 – 6
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HMC
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Development of cancers
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7 – 8
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HMC
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Cell cycle control, cell death mechanisms in cancer
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9-10
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LM
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DNA processes and associated cancer prone syndromes
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11-12
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HMC
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Viruses & genetic factors in cancer
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RM
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Transcription factors in cancer
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13-14
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HMC
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Haematological malignancies
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15-16
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HMC
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Breast, colon and lung cancer
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17-18
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HMC
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Cancer chemoprevention
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19-20
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CI/LM
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Dietary factors influencing cancer development
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21-22
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HMC
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Cancer therapy: conventional cancer chemotherapy
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23-24
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HMC
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Drug resistance in cancer
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New targets and therapies for cancer (1)
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25-26
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HMC
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New targets and therapies for cancer (2)
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27-28
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HMC
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Case studies
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29-30
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HMC
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Revision session
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| Methods of Teaching/Learning |
Lectures |
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| Selected Texts/Journals |
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Recommended Books:
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Molecular Biology of Cancer, L Pecorino,
Oxford
University
Press, 2nd Edition. ISBN: 0199264724 (£24.88)
Molecular Biology of Human Cancers: an advanced student’s textbook by Wolfgang Arthur Schulz, Springer £35.00 ISBN 978-1-40206559-0
A recently published book on "The Biology of Cancer" by Robert A Weinburg, ISBN: 0815340761 published by Garland Science (2006), is most impressive at first sight, but contains far more information that you need at this stage. However, those of you who are hoping to go on to do medicine or get involved in cancer research might consider purchase as it will last. (price: £41.99 - paperback)
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| Last Updated |
| 15 April 2011 |
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