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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE
 Module Code: BMS3061 Module Title: PATHOGENESIS OF INFECTIOUS DISEASE
Module Provider: Biosciences Short Name: BMS3061
Level: HE3 Module Co-ordinator: LOCKER NS Dr (Biosciences)
Number of credits: 15 Number of ECTS credits: 7.5
 
Module Availability
Semester One
Assessment Pattern

Coursework: Critical essay (set in week 1 and submitted week 10) 30% Examination 70%
Module Overview
Prerequisites/Co-requisites
Module Aims

To use specific examples of diseases caused by bacteria, viruses and protozoa to illustrate and explore aspects of microbial disease pathogenesis including:  

  • Virulence mechanisms
  • Toxins
  • Secretion systems
  • Intracellular survival
  • Immunity
  • Disease
  • Autoimmunity  
Learning Outcomes

On successful completion of this module you should be able to:- 

  • Describe the pathogenesis of a range of bacterial, viral and protozoal diseases including diseases caused by enteric bacteria, neisseria, mycobacteria, legionella, staphylococci, streptococci, protozoa and major human viruses  
  •  Describe structure-function relationships for bacterial toxins.
  • Discuss what is meant by a virulence gene
  • Describe the role of type III secretion systems in pathogenesis
  • Describe how bacteria and viruses survive and replicate intracellularly
  • Describe how bacteria and viruses regulate genes in response to the host environment
  • Discuss how microbes and viruses interact with host defences to cause disease pathology 
  • Discuss how microbes and viruses interact with host defences to cause immune pathology
Module Content

Lecture No:

Lecturer

Topic

1 - 2

SFP

Bacterial toxins

3 - 4  

SFP

Intracellular survival of bacterial pathogens

4 - 6

JJM

Type III secretion systems in enteric bacteria

 

 

Host Pathogen interactions in:

7 - 8

JJM

                                               Neisseria

8 - 9

GS

                                               Mycobacteria

9 - 10

DBeste

                                               Staphylococcus and Streptococci

11 - 12

PBates

                                                Protozoa

13-14

NL

Viruses and cell transformation

15-16

NL

Influenza viruses

17-18

NL

Retroviruses, Human T-Cell lymphotropic virus

19-20

NL

HIV and AIDS

21-22

NL

Blood-born Hepatitis: B, C, D and E

23-24

NL

Herpes viruses: Simplex, Varicella zoster, Cytomegalovirus and Epstein Barr

25

NL

Viral gastroenteritis

26

NL

Enteroviruses and hepatitis E

27

NL

RNA silencing and viruses

Methods of Teaching/Learning
Lectures
Selected Texts/Journals
Recommended Textbooks:

A A Salyers & D D Whitt: Bacterial Pathogenesis. 2nd Ed. ASM Press (2002).

 

 

Fundamentals of Molecular Virology. N.H. Acheson. Wiley. (2007)

 

 

Viruses and Human Disease. Strauss and Strauss. Academic Press. (2002)

 

 

Schaechter's Mechanisms of Microbial Disease (Schaechter). 4th Ed. Lippincott Williams and Wilkins (2006).
Last Updated

20 April 2011