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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE
 Module Code: BMS3060 Module Title: BIOMEDICAL MICROBIAL PRODUCTS
Module Provider: Biosciences Short Name: BMS3060
Level: HE3 Module Co-ordinator: BUSHELL ME Prof (Biosciences)
Number of credits: 15 Number of ECTS credits: 7.5
 
Module Availability
Semester One
Assessment Pattern

Coursework  50% Practical write-up (to be submitted on Friday week 11)

 

Examination  50%

 
Module Overview
Prerequisites/Co-requisites
Module Aims
  • To familiarise students with the range of microbial products and obtain a working knowledge of technology for their production
  •  To demonstrate the physiology of over-production
  • To teach manipulative skills relevant to the isolation, recognition and culture of product-forming microorganisms
  • To provide practical experience of issues arising from the lecture content
  • To demonstrate a semi-automated approach to handling large numbers of microorganisms

     

 
Learning Outcomes

On successful completion of this module you should be able to:-

 

 

·                    Distinguish between the physiological events responsible for inducing the synthesis of a range of products

 

 

·                    Identify  research strategies for the development of new bioproducts

 

 

·                    Distinguish between screens that rely on positive selection and neutral selection for

 

Bioproduct - synthesising cultures

 

 

·                    Apply modern methods of report preparation, data reduction, data presentation and

 

literature searching

 

 
Module Content

Lecture No:

 

Lecturer

 

Topic

 

 

 

 

1

 

MEB

 

Range of biomedical products

 

2

 

MEB

 

Secondary metabolism (why and how do microbes make antibiotics?)

 

3

 

MEB

 

Secondary metabolism (how can we use this information to our advantage?)

 

4

 

MEB

 

Penicillin

 

5

 

MEB

 

Penicillin

 

6

 

MEB

 

Other antibiotics

 

7

 

MEB

 

New bioproduct medicine discovery

 

8

 

MEB

 

New  bioproduct medicine discovery

 

9

 

MEB

 

Uses and production of enzymes

 

10

 

MEB

 

Uses and production of enzymes

 

11

 

MEB

 

Potable alcohol

 

12

 

MEB

 

Single cell protein

 

13

 

MEB

 

Organic acids

 

14

 

MEB

 

Amino acids

 

15

 

MEB

 

Growth dynamics relevant to product formation

 

16

 

MEB

 

Simple reactor systems

 

17

 

MEB

 

Advanced reactor systems

 

18

 

MEB

 

Physiological control

 

19

 

MEB

 

Recombinant DNA products

 

20

 

MEB

 

Medical product economics

 

 

 

 

Practical No:

 

(to be run in parallel with the lectures)

 

Lecturer

 

Topic

 

1-3

 

MEB

 

lsolation of antibiotic and cellulase-producing micro-organisms from various habitats

 

4-6

 

MEB

 

Subculture of isolates

 

7-9

 

MEB

 

Purity checks, re-isolation and subculture

 

10-12

 

MEB

 

Droplet culture and assay for antibiotic-producers (1)

 

13-15

 

MEB

 

Droplet culture and assay for antibiotic-producers (2)

 

16-18

 

MEB

 

Select and re-sub selected strains

 

19-21

 

MEB

 

Make up seed flask liquid cultures

 

22-24

 

MEB

 

Production liquid cultures

 

25-27

 

MEB

 

Assay liquid cultures for bioactivity

 

28-30

 

MEB

 

Excel data analysis tutorial

 
Methods of Teaching/Learning
Lectures, Practical
Selected Texts/Journals
Last Updated
15 April 2011