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| Module Availability |
| Semester One |
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| Assessment Pattern |
Coursework - 20%
Examination - 80%
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Coursework:
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At least one essay or problem from a choice of five. Provisional deadlines Monday week 4 (essay 1), Monday week 8 (essays 2 and 3), Monday week 11 of semester (essays 4 and 5).
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| Module Overview |
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This module builds on the basic principles covered in Pharmacology I, and explores in more detail some of the neurotransmitters and mediators which control body functions and the ways in which drugs can affect these and how this could have potential therapeutic benefits. It also covers in more detail the way in which drugs are metabolised by the body, as well as presenting the basic principles of pharmacokinetics, the way in which drug concentrations change in the body after drug administration.
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| Prerequisites/Co-requisites |
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| Module Aims |
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To provide a selective understanding of neurotransmitters and mediators in the periphery and the CNS
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To provide an understanding of the enzymology, molecular biology, regulation and chemistry of drug metabolism
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To provide a theoretical understanding of the kinetic disposition of drugs
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To focus on systems of current interest as active research areas and areas of potential drug development
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| Learning Outcomes |
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On successful completion of this module you should be able to describe:
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How neurotransmitters and mediators are involved in physiological functions
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How neurotransmitters and mediators are altered in disease and can be targets for drugs
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How metabolism influences drug action
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How the basic concepts of chemistry, biochemistry and physiology integrate in drug metabolism
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The reasons why inter-individual variations in drug response occur
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| Module Content |
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Lecture No
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Lecturer
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Topic
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1
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SMOH
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Purines as neurotransmitters and mediators
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2
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SMOH
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Purines as neurotransmitters and mediators
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3
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SMOH
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NO as a neurotransmitter and mediator
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4
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SMOH
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NO as a neurotransmitter and mediator
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5
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SMOH
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Lipid-derived mediators
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6
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SMOH
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Lipid-derived mediators
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7
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SMOH
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Tutorial - haemostasis, thrombosis and inflammation
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8
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RW
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Cannabinoids
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9
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RW
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5-HT
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10
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RW
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5-HT
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11
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RW
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Dopamine
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12
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RW
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Dopamine
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13
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RW
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Neuropeptides
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14
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RW
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Neuropeptides
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15
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YC
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Acetylcholine
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16
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YC
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Glutamate
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17
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YC
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Glutamate
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18
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YC
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GABA
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19
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YC
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GABA
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20
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RW/YC
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Tutorial - CNS transmitter systems
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21
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CI
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Pharmacokinetics
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22
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CI
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Pharmacokinetics
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23
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CI
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Pharmacokinetics
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24
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CI
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Pharmacokinetics
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25
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AET
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Phase 1 Drug metabolism
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26
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AET
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Phase 1 Drug metabolism
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27
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AET
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Phase 2 Drug metabolism
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28
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AET
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Phase 2 Drug metabolism
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29
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NJP
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Factors affecting drug metabolism
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30
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NJP
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Factors affecting drug metabolism
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| Methods of Teaching/Learning |
| Lectures, tutorials |
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| Selected Texts/Journals |
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| Last Updated |
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