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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE
 Module Code: BMS3053 Module Title: MOLECULAR BIOLOGY AND GENETICS 3
Module Provider: Biosciences Short Name: BMS3053
Level: HE3 Module Co-ordinator: MCFADDEN J Prof (Biosciences)
Number of credits: 15 Number of ECTS credits: 7.5
 
Module Availability
Assessment Pattern

Coursework:  Critical essay (20%) and group presentation (10%) submission deadline: Week 10

 

Examination: 70% choice of 2/5 questions
Module Overview
Prerequisites/Co-requisites
Module Aims

To examine the molecular genetics of prokaryotes and eukaryotes with particular emphasis on:-

  • Genomic structure, organisation and genomics
  • Control of gene expression in prokaryotes and eukaryotes
  • The genetic control of differentiation and development in prokaryotes and eukaryotes
  • The role of genetic alterations (mutation and epigenetic) in health and disease
  • The use of molecular genetic techniques to understand the aetiology of disease
  • The use of molecular genetic analysis to understand the evolutionary process

     

Learning Outcomes

On successful completion of this module you should be able to understand:-

  • How genome structure and replication relates to function
  • How organisms regulate gene expression in response to changes in their environment
  • How genetic regulation governs differentiation and development in prokaryotes and eukaryotes
  • The role that genetic variation plays in heath and disease of humans
  • How molecular evolution has shaped life on our planet

You should also be able to:

  • Critically assess research papers in these fields
  • Present research papers in this field

     

Module Content

Lecture No:

 

Lecturer

 

Topic

 

1

 

JJM

 

Introduction to critical essay and presentation

 

2

 

FRG

 

Chromosome organisation and replication

 

3

 

FRG

 

Chromosome organisation and replication

 

4

 

CPS

 

Prokaryotic development: sporulation in Bacillus

 

5

 

CPS

 

Prokaryotic development: antibiotic synthesis in Streptomyces

 

6

 

NJP

 

Basic concepts of transcriptional regulation

 

7

 

NSL

 

Translational control and disease - 1

 

8

 

NSL

 

Translational control and disease - 2

 

9

 

NJP

 

Combinatorial control as a control mechanism

 

10

 

NJP

 

Epigenetics and transgenerational inheritance

 

11

 

NJP

 

Case Study:  Drosophila embryogenesis

 

12

 

NJP

 

Case Study:  The homeobox (Hox) Gene Family

 

13

 

FRG

 

Basic concepts:  The inheritance of disease

 

14

 

FRG

 

Basic concepts:  Genetic variation and quantitative genetics - 1

 

15

 

FRG

 

Basic concepts:  Genetic variation and quantitative genetics - 2

 

16

 

KEP

 

Molecular genetics of chromosomal disorders - 1

 

17

 

KEP

 

Molecular genetics of chromosomal disorders - 2

 

18

 

MvS

 

Molecular genetics of neurological disorders – 1

 

19

 

MvS

 

Molecular genetics of neurological disorders - 2

 

20

 

FRG

 

Molecular genetics of cardiovascular disorders - 1

 

21

 

FRG

 

Molecular genetics of cardiovascular disorders - 2

 

22

 

RM

 

Molecular genetics of cancer syndrome - 1

 

23

 

RM

 

Molecular genetics of cancer syndrome - 2

 

24

 

MvS

 

Molecular genetics of the eye – 1

 

25

 

MvS

 

Molecular genetics of the eye – 2

 

26

 

JMcF

 

Molecular Evolution -1

 

27

 

JMcF

 

Molecular Evolution - 2

 

28

 

JMcF

 

Molecular Evolution - 3

 

29

 

JMcF

 

Molecular Evolution - 4

 

30

 

 

Tutorial

 

31

 

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Critical Essay Presentation

 

32

 

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Critical Essay Presentation

 

Methods of Teaching/Learning
Lectures
Selected Texts/Journals

Recommended Books:

 

Molecular Biology of the Cell. Lewis, Raff, Bray , Alberts ( Garland Science, 2008).

 

Human Molecular Genetics, Strachan and Read ( Garland Science, 2010)

 

Last Updated
15 April 2011