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| Module Availability |
| Semester One |
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| Assessment Pattern |
Coursework - 30% (Students will be randomly allocated one of three pieces of coursework (RJ, AET, tbc), submission deadline 1 week after completion of relevant lecture block
Examination - 70% (to be sub-divided into three sections, of which students have to answer at least one question per section)
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| Module Overview |
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This module is divided into four broad topics, namely Metabolic Control by Nuclear Receptors, using the Peroxisome Proliferator-Activated Receptors (PPAR) as the main examples; Bioenergetics and Oxidative Phosphorylation; Biological Membranes, including transport processes; Signalling Pathways, including (1) membrane-bound (G-protein coupled receptors; enzyme linked receptors families; death receptors) and intracellular receptors (e.g. guanylyl cyclase), (2) secondary messengers, e.g. Ca2/sup>, and (3) Mitogen-Activated Protein Kinases (MAPK)
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| Prerequisites/Co-requisites |
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| Module Aims |
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To provide an understanding of the molecular mechanisms which underlie metabolic regulation, with a focus on the role of nuclear receptors
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Bioenergetics
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Oxidative phosphorylation
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Biological membranes and transport
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To provide an understanding of receptor signalling at the molecular level
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To provide information about second messenger coupling systems and receptor regulation
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| Learning Outcomes |
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On successful completion of this module you should:-
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Demonstrate a sound knowledge of the integration of metabolic pathways
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Identify how plasma membrane and nuclear receptors control cellular function
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Understand the key role of nuclear receptors in the control of metabolism, with specific reference to fatty acids and cholesterol
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Bioenergetics
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Oxidative phosphorylation
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Biological membranes and transport
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| Module Content |
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Lecture No:
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Lecturer
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Topic
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1-8
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AET
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Overview of metabolic pathways and their integration;
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General properties of nuclear receptors;
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Peroxisome Proliferator Activated Receptors (PPAR's): Structure and function;
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Sterol regulatory element binding proteins (SREBP): Structure and function
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9-14
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tbc
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Bioenergetics
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Oxidative phosphorylation
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15-25
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RJ
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Biological membranes and transport
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Receptors, second messengers and downstream signalling
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26
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AET
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Coursework feedback & revision tutorial
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27
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tbc
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Coursework feedback & revision tutorial
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28
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RJ
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Coursework feedback & revision tutorial
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| Methods of Teaching/Learning |
| Lectures, tutorials |
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| Selected Texts/Journals |
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Recommended Books:
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Lodish et al., Molecular Cell Biology, 6th Edition (2007)
Alberts et al., Molecular Biology of the Cell, 5th Edition (2008)
Papers and reviews, as referenced in lectures
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| Last Updated |
| 4 May 2011 |
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