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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE
 Module Code: BMS3052 Module Title: BIOCHEMISTRY - RECEPTORS AND ENERGY METABOLISM
Module Provider: Biosciences Short Name: BMS3052
Level: HE3 Module Co-ordinator: THUMSER AE Dr (Biosciences)
Number of credits: 15 Number of ECTS credits: 7.5
 
Module Availability
Semester One
Assessment Pattern

Coursework  -  30% (Students will be randomly allocated one of three pieces of coursework (RJ, AET, tbc), submission deadline 1 week after completion of relevant lecture block

Examination  -  70% (to be sub-divided into three sections, of which students have to answer at least one question per section)

Module Overview

This module is divided into four broad topics, namely Metabolic Control by Nuclear Receptors, using the Peroxisome Proliferator-Activated Receptors (PPAR) as the main examples; Bioenergetics and Oxidative Phosphorylation; Biological Membranes, including transport processes; Signalling Pathways, including (1) membrane-bound (G-protein coupled receptors; enzyme linked receptors families; death receptors) and intracellular receptors (e.g. guanylyl cyclase), (2) secondary messengers, e.g. Ca2/sup>, and (3) Mitogen-Activated Protein Kinases (MAPK)

 

Prerequisites/Co-requisites
Module Aims
  • To provide an understanding of the molecular mechanisms which underlie metabolic regulation, with a focus on the role of nuclear receptors
  • Bioenergetics 
  • Oxidative phosphorylation 
  • Biological membranes and transport
  • To provide an understanding of receptor signalling at the molecular level
  • To provide information about second messenger coupling systems and receptor regulation
Learning Outcomes

On successful completion of this module you should:-

  • Demonstrate a sound knowledge of the integration of metabolic pathways
  • Identify how plasma membrane and nuclear receptors control cellular function
  • Understand the key role of nuclear receptors in the control of metabolism, with specific reference to fatty acids and cholesterol
  • Bioenergetics 
  • Oxidative phosphorylation
  • Biological membranes and transport
Module Content

Lecture No:

Lecturer

Topic

1-8

AET

Overview of metabolic pathways and their integration;

 

 

General properties of nuclear receptors;

 

 

 

 

Peroxisome Proliferator Activated Receptors (PPAR's): Structure and function;

 

 

Sterol regulatory element binding proteins (SREBP): Structure and function

9-14

tbc

Bioenergetics

 

 

Oxidative phosphorylation

15-25

RJ

Biological membranes and transport

 

 

Receptors, second messengers and downstream signalling

26

AET

Coursework feedback & revision tutorial

27

tbc

Coursework feedback & revision tutorial

28

RJ

Coursework feedback & revision tutorial

Methods of Teaching/Learning
Lectures, tutorials
Selected Texts/Journals

Recommended Books:

Lodish et al., Molecular Cell Biology, 6th Edition (2007)

Alberts et al., Molecular Biology of the Cell, 5th Edition (2008)

Papers and reviews, as referenced in lectures

Last Updated
4 May 2011