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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE
 Module Code: BMS1033 Module Title: FURTHER CHEMISTRY
Module Provider: Biosciences Short Name: BMS1033
Level: HE1 Module Co-ordinator:
Number of credits: 15 Number of ECTS credits: 7.5
 
Module Availability
Semester Two
Assessment Pattern

Coursework:     Practical write ups = 40%  (Submission deadline TBC)

Examination:   120min (Section A (10 short questions): Attempt as many as possible (60min); Section B (long questions) answer 2 out of 3 questions (60min)) – 60%

Module Overview
Prerequisites/Co-requisites
None
Module Aims
  •  To provide an understanding of the nature of solutions with particular reference to biological systems
  •  To provide an understanding of the physical properties of solutions of macromolecules
  •  To provide an understanding of fundamental concepts in electrochemistry and thermodynamics as well as their applications
  •  To give an introduction to the subject of reaction kinetics in solution
  •  To relate the rates of chemical reactions to parameters such as concentration, temperature, acidity and basicity 
  •  To derive the various equations for zero, first and second order reactions so that experimental data can be handled in an appropriate manner
  •  To provide an introduction to the use of isotopes
  •  To enhance organic and physical chemistry laboratory skills
Learning Outcomes

On successful completion of this module you should be able to:-

  • Understand the concept of non-ideality in terms of interactions and its application to solutions of macromolecules
  • Understand theory of acids, bases and buffer solutions
  • Perform simple calculations with the help of a list of basic equations
  • Understand the use of conductance measurements for investigating the behaviour of electrolytes in solution 
  • Understand the use of emf measurements for the derivation of thermodynamic parameters
  • Understand the significance of rate, rate constant, order, rate-determining step and mechanism
  • Know how the concentration of reactants change with time for zero, first and second order reactions, as well as first-order reversible reactions so that the relevant rate constants can be calculated
  • Be able to calculate the energy of activation for a particular reaction from the dependence of the rate constant on temperature
  • Carry out a range of organic physical chemistry techniques
  • Quantitatively evaluate physico-chemical experimental data

 

 
Module Content

Lecture No:

Staff

Topic

1 - 8

 

 

 

JP

 

 

 

Reaction kinetics (reaction order, rate determining step, integrated rate equations, consecutive reactions, effect of temperature, introduction to Michaelis-Menten kinetics)

9 - 12

JP  

Solutions (colligative properties, electrolytes, acids and bases, pH regulation-buffer solutions) 
Macromolecules (structure, solvents, folding, unfolding)

12 - 14

JP

Energetics and equilibria (Gibbs energy, enthalpy, entropy)

15 - 20  

SMR

 

 

Electrochemistry (electrochemical cells, standard reference electrodes, redox systems, Nernst equation, glass and neutral carrier electrodes.  Conductance measurements.  Applications

21 – 29

 

 

 

CAA

   

Bioinorganic chemistry (metal ions in biological processes - essential and toxic, coordination chemistry, geometries, complex stability, iron-porphyrin ligands, metalloenzymes, chelate effect and stability constants)

30-36

 

    37-45













 

 

 

 

IDC/MP

 

 JP

2 x 3 hour Organic chemistry practicals ( isolation of caffeine from tea, steam distillation of eugenol) plus pre-lab

3 X 3 physical chemistry practicals, enthalpy, kinetics and partition coefficients
Methods of Teaching/Learning
Selected Texts/Journals

 Recommended Textbook:
Price N, Dwek R, Ratcliffe R and Wormald M (2001 revised reprint) Principles and Problems in Physical Chemistry for Biochemists, 3rd edition, Oxford University Press. 

Fenton D (1995) Biocoordination Chemistry, OUP ( Oxford chemistry primer series) 
Read, Holmes, Weyers and Jones Practical skills in Biomolecular Sciences, Pearson

Also Consult:

Logan S R (1998) Physical Chemistry for the Biomedical Sciences, Taylor and Francis 

Lippard S J and Berg J M (1994)  Principles of Bioinorganic Chemistry, Freeman

Morris G (1974) A Biologist's Physical Chemistry, 2nd edition,   Arnold (useful but out of print)

Chang R (2000) Physical Chemistry for the Chemical and Biological Sciences, University Science Books

Reference Texts:

Atkins P W (2000) The Elements of Physical Chemistry, 3rd edition, OUP 
Lide D E ed (1995)  Handbook of Chemistry and Physics, 76th edition, CRC Press

Last Updated
5 April 2011