BMS1031


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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE

Module Code: BMS1031

Module Title: MOLECULAR BIOLOGY AND GENETICS 1

Module Provider: Biosciences	Short Name: BMS1031
Level: HE1	Module Co-ordinator: SMITH CP Prof (Biosciences)
Number of credits: 15	Number of ECTS credits: 7.5

Module Availability

Semester Two

Assessment Pattern

Coursework: Reports on three practicals; weighting = 30%

Deadline 2 weeks after each practical session

Examination: 90 min (100 multiple choice questions); weighting 70%; this examination will cover the whole module

Module Overview

Prerequisites/Co-requisites

None

Module Aims

To obtain a basic understanding of the molecular biology of bacteria (prokaryotes) and eukaryotes
To provide an appreciation of the use of microbiological and molecular genetic skills in biomedical and clinical research laboratories
To enhance the understanding of the lectures on bacterial and molecular genetics

Learning Outcomes

On successful completion of this module you should be able to explain:-

The basis of gene structure and function
How regulation of gene expression relates to structure and function at the cellular level
The relationship of protein structure to biological activity
Important differences in gene structure and function between prokaryotes and eukaryotes
How to evaluate quantitative data on bacterial molecular genetics

Module Content

Lecture No:	Staff	Topic
1	JBM	DNA Structure - the double helix
2	JBM	DNA replication: strategy and mechanism
3	JBM	RNA structure - tRNA, rRNA, mRNA
4	JBM	RNA transcription and processing
5	JBM	Protein biosynthesis 1: the genetic code, codons, tRNA activation
6	JBM	Protein biosynthesis 2: initiation, elongation, termination
7	JBM	Protein structure 1: primary structure and secondary structure
8	JBM	Protein structure 2: tertiary and quaternary structure
9	JBM	MCQ class tutorial on lecture material covered by JBM
3 hr practical	GRS	Practical 1 Plasmids, transfer of antibiotic resistance
10	CPS	Mutation and repair
11	CPS	Gene regulation in bacteria - 1: basic concepts and lactose operon
12	CPS	Gene regulation in bacteria - 2: glucose repression and positive regulation
3 hr practical	GRS	Practical 2 Bacteriophage, propagation, bacterial ‘mating’
13	CPS	Gene regulation in bacteria - 3: analysis of regulatory mutants
14	CPS	Gene regulation in bacteria - 4: anabolic systems – the tryptophan operon
15	CPS	Bacteriophages, plasmids and natural gene transfer
3 hr practical	GRS	Practical 3 Analysis of propagation and gene transfer
16	CPS	DNA recombination: generalised and transposition
17	CPS	Gene cloning: tools and basic concepts
18	CPS	MCQ class tutorial on lecture material covered by CPS
19	FG	Eukaryotic chromatin structure
20	FG	Eukaryotic gene organisation, ‘split genes’, gene families
21	FG	Eukaryotic gene expression 1: promoters, control of transcription
22	FG	Eukaryotic gene expression 2: mRNA abundance, alternative splicing
23	FG	Human Genetics 1
24	FG	Human Genetics 2
25	FG	Human Genetics 3
26	FG	MCQ class tutorial on lecture material covered by FG

Methods of Teaching/Learning

Practical

Selected Texts/Journals

Recommended Textbook:
Alberts, B. et al. (2008) Molecular Biology of the Cell, Fifth edition, Garland Publishing (same textbook recommended for several other modules)
[See also Wilson, J. & Hunt, T. (2007) Molecular Biology of the Cell, Fifth edition: The Problems Book]

Also Consult:

Lodish, H., et al (2008) Molecular Cell Biology, 6^th Edition, W.H. Freeman

Berg, J. et al (2006) Biochemistry, 6^th edition, W.H. Freeman

Dale, J and Park, S. (2004) Molecular Genetics of Bacteria, 4^th edition, Wiley

Last Updated

5 April 2011

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