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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE
 Module Code: BMS1031 Module Title: MOLECULAR BIOLOGY AND GENETICS 1
Module Provider: Biosciences Short Name: BMS1031
Level: HE1 Module Co-ordinator: SMITH CP Prof (Biosciences)
Number of credits: 15 Number of ECTS credits: 7.5
 
Module Availability
Semester Two
Assessment Pattern

Coursework:   Reports on three practicals; weighting  =  30%

                           Deadline 2 weeks after each practical session

Examination: 90 min (100 multiple choice questions); weighting 70%; this examination will cover the whole module

Module Overview
Prerequisites/Co-requisites
None
Module Aims
  • To obtain a basic understanding of the molecular biology of bacteria (prokaryotes) and eukaryotes
  • To provide an appreciation of the use of microbiological and molecular genetic skills in biomedical and clinical research laboratories
  • To enhance the understanding of the lectures on bacterial and molecular genetics

     

Learning Outcomes

On successful completion of this module you should be able to explain:- 

  • The basis of gene structure and function
  • How regulation of gene expression relates to structure and     function at the cellular level 
  • The relationship of protein structure to biological activity
  • Important differences in gene structure and function between prokaryotes and eukaryotes
  • How to evaluate quantitative data on bacterial molecular genetics
Module Content

Lecture No:

Staff

Topic

1

JBM

DNA Structure - the double helix

2

JBM

DNA replication: strategy and mechanism

3

JBM

RNA structure - tRNA, rRNA, mRNA

4

JBM

RNA transcription and processing

5

JBM

Protein biosynthesis 1:  the genetic code, codons, tRNA activation

6

JBM

Protein biosynthesis 2:  initiation, elongation, termination 

7

JBM

Protein structure 1:  primary structure and secondary structure

8

JBM

Protein structure 2:  tertiary and quaternary structure

9

JBM

MCQ class tutorial on lecture material covered by JBM

3 hr practical

GRS  

Practical 1  Plasmids, transfer of antibiotic resistance

10

CPS

Mutation and repair

11

CPS

Gene regulation in bacteria - 1: basic concepts and lactose operon

12

CPS

Gene regulation in bacteria - 2: glucose repression and positive regulation

3 hr practical

GRS

Practical 2  Bacteriophage, propagation, bacterial ‘mating’  

13

CPS

Gene regulation in bacteria - 3: analysis of regulatory mutants

14

CPS

Gene regulation in bacteria - 4: anabolic systems – the tryptophan operon

15

CPS 

Bacteriophages, plasmids and natural gene transfer

3 hr practical

GRS

Practical 3  Analysis of propagation and gene transfer

16

CPS

DNA recombination: generalised and transposition

17

CPS

Gene cloning: tools and basic concepts  

18

CPS

MCQ class tutorial on lecture material covered by CPS

19

FG

Eukaryotic chromatin structure

20

FG

Eukaryotic gene organisation, ‘split genes’, gene families

21

      FG

Eukaryotic gene expression 1: promoters, control of transcription

22

FG

Eukaryotic gene expression 2: mRNA abundance, alternative splicing

23

FG

Human Genetics 1

24

FG

Human Genetics 2

25

FG

Human Genetics 3

26

FG  

MCQ class tutorial on lecture material covered by FG

Methods of Teaching/Learning
Practical
Selected Texts/Journals

Recommended Textbook:
Alberts, B. et al.  (2008)  Molecular Biology of the Cell, Fifth edition, Garland
Publishing  (same textbook recommended for several other modules) 
[See also Wilson, J. & Hunt, T. (2007) Molecular Biology of the Cell, Fifth edition: The Problems Book]

Also Consult:

Lodish, H., et al (2008)  Molecular Cell Biology, 6th  Edition, W.H. Freeman

Berg, J. et al (2006) Biochemistry, 6th edition, W.H. Freeman

Dale, J and Park, S. (2004) Molecular Genetics of Bacteria, 4th edition, Wiley

Last Updated
5 April 2011