|
| Module Availability |
Semester Two |
|
|
| Assessment Pattern |
|
2 practical write-ups: 20%, submission deadline 2 weeks after practicals have run.
Examination: 80% (MCQ or short answer questions)
|
|
|
|
| Module Overview |
|
|
|
| Prerequisites/Co-requisites |
| None |
|
|
| Module Aims |
- To give an appreciation of the basic structure of biologically important molecules (biochemical building blocks and macromolecules) and their biological roles
- To introduce the fundamental biological chemistry of living systems – biological reactions and their organization in metabolic pathways
- To explore how living systems derive energy from nutrients and utilise it for their functions
- To explain how nutrients are oxidised using oxygen, and to explain the inter-relationships that exist between different metabolic pathways
- To explain how the simple compounds derived from complex nutrients are used to build the macromolecules essential to life
- To visualize metabolism as the co-ordinated activity of the biochemical transformations in living organisms
|
|
|
| Learning Outcomes |
On successful completion of this module you should be able to:-
-
Recognise the different biologically relevant molecules and their functions
-
Recognise the structure of complex biological molecules and identify and discuss their roles
-
Identify the enzymes and cofactors that have central roles in metabolism
-
Describe the principal pathways and cycles in biochemical metabolism
-
Explain how ATP is produced and utilised in biological systems
|
|
|
| Module Content |
|
Lecture hours
|
Staff
|
Topic
|
|
10
10
|
AET
AET
AET
AET
AET
TBC
TBC
TBC
TBC
|
Introduction to Biochemistry.
Amino acids and proteins.
Protein structure and function.
Enzymes and enzyme kinetics.
Lipids and lipid metabolism
Carbohydrates and Polysaccharides, structure and function. Sugars and their role as metabolic fuels.
Metabolism of amino acids and the urea cycle Metabolic defects of amino acid metabolism The pentose phosphate pathway as a source of reduced co-factors and precursors
|
|
9
|
CA-R
|
Glycolysis as the central pathway of primary metabolism. Glycogenolysis and gluconeogenesis.
|
|
|
CA-R
|
Metabolic fate of Pyruvate. AcetylCoA as point of convergence of catabolism
|
|
|
CA-R
|
Overview of the TCA cycle. Oxidative phosphorylation and ATP production.
|
|
1
|
DS
|
Pre-practical lecture
|
|
3
|
DS
|
Practical 1: Measurement of protein concentration
|
|
1
|
AB
|
Pre-practical lecture
|
|
3
|
AB
|
Practical 2: Enzyme kinetics: determination of the progress curve and effect of the variation of substrate concentration
|
|
3
|
CA-R / AET / TBC
|
Tutorials on lectures
|
|
|
|
| Methods of Teaching/Learning |
| Lectures, practicals |
|
|
| Selected Texts/Journals |
Recommended Textbook:
Biochemistry - Harvey R A (2010) 5th edition, LW&W
Pain-free Biochemistry: An essential guide for the health sciences. Engel PC (2009), Wiley-Blackwell.
Lehninger Principles of Biochemistry - Nelson D L and Cox M M (2008) 5th Edition, Freeman - ISBN 9781429208925
Biochemistry - Berg J M, et. al., (2006) 6th edition, Freeman
Textbook of Biochemistry with Clinical Correlations - Devlin T M (2002) 5th edition, Wiley
|
|
|
| Last Updated |
| 5 April 2011 |
|
