BMS1030


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2011/2 Provisional Module Catalogue - UNDER CONSTRUCTION & SUBJECT TO CHANGE

Module Code: BMS1030

Module Title: BIOCHEMISTRY

Module Provider: Biosciences	Short Name: BMS1030
Level: HE1	Module Co-ordinator: AVIGNONE ROSSA CA Dr (Biosciences)
Number of credits: 15	Number of ECTS credits: 7.5

Module Availability

Semester Two

Assessment Pattern

2 practical write-ups: 20%, submission deadline 2 weeks after practicals have run.
Examination: 80% (MCQ or short answer questions)

Module Overview

Prerequisites/Co-requisites

None

Module Aims

To give an appreciation of the basic structure of biologically important molecules (biochemical building blocks and macromolecules) and their biological roles
To introduce the fundamental biological chemistry of living systems – biological reactions and their organization in metabolic pathways
To explore how living systems derive energy from nutrients and utilise it for their functions
To explain how nutrients are oxidised using oxygen, and to explain the inter-relationships that exist between different metabolic pathways
To explain how the simple compounds derived from complex nutrients are used to build the macromolecules essential to life
To visualize metabolism as the co-ordinated activity of the biochemical transformations in living organisms

Learning Outcomes

On successful completion of this module you should be able to:-

Recognise the different biologically relevant molecules and their functions
Recognise the structure of complex biological molecules and identify and discuss their roles
Identify the enzymes and cofactors that have central roles in metabolism
Describe the principal pathways and cycles in biochemical metabolism
Explain how ATP is produced and utilised in biological systems

Module Content

Lecture hours	Staff	Topic
10 10	AET AET AET AET AET TBC TBC TBC TBC	Introduction to Biochemistry. Amino acids and proteins. Protein structure and function. Enzymes and enzyme kinetics. Lipids and lipid metabolism Carbohydrates and Polysaccharides, structure and function. Sugars and their role as metabolic fuels. Metabolism of amino acids and the urea cycle Metabolic defects of amino acid metabolism The pentose phosphate pathway as a source of reduced co-factors and precursors
9	CA-R	Glycolysis as the central pathway of primary metabolism. Glycogenolysis and gluconeogenesis.
	CA-R	Metabolic fate of Pyruvate. AcetylCoA as point of convergence of catabolism
	CA-R	Overview of the TCA cycle. Oxidative phosphorylation and ATP production.
1	DS	Pre-practical lecture
3	DS	Practical 1: Measurement of protein concentration
1	AB	Pre-practical lecture
3	AB	Practical 2: Enzyme kinetics: determination of the progress curve and effect of the variation of substrate concentration
3	CA-R / AET / TBC	Tutorials on lectures

Methods of Teaching/Learning

Lectures, practicals

Selected Texts/Journals

Recommended Textbook:
Biochemistry - Harvey R A (2010) 5th edition, LW&W

Pain-free Biochemistry: An essential guide for the health sciences. Engel PC (2009), Wiley-Blackwell.

Lehninger Principles of Biochemistry - Nelson D L and Cox M M (2008) 5^th Edition, Freeman - ISBN 9781429208925

Biochemistry - Berg J M, et. al., (2006) 6th edition, Freeman

Textbook of Biochemistry with Clinical Correlations - Devlin T M (2002) 5th edition, Wiley

Last Updated

5 April 2011